![]() Note: Limit use to ≤3 days per month to avoid medication overuse headache (Garza 2006) studies have found increased risk with use of ≥5 days per month (Da Silva 2014). ![]() Hypersensitivity or intolerance to any component of the formulation porphyria Dosage and Administration Dosing: Adult Tension or muscle contraction headache: Relief of symptom complex of tension or muscle contraction headache Contraindications Pharmacokinetics/Pharmacodynamics Absorptionīutalbital: Urine (59% to 88% as unchanged drug and metabolites) Half-Life Elimination Antipyresis is produced from inhibition of the hypothalamic heat-regulating center.Ĭaffeine: Increases levels of 3'5' cyclic AMP by inhibiting phosphodiesterase CNS stimulant which increases medullary respiratory center sensitivity to carbon dioxide, stimulates central inspiratory drive, and improves skeletal muscle contraction (diaphragmatic contractility). Interactions with other nociceptive systems may be involved as well (Smith 2009). Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar function, and produce drowsiness, sedation, hypnosis, and dose-dependent respiratory depression.Īcetaminophen: Although not fully elucidated, the analgesic effects are believed to be due to activation of descending serotonergic inhibitory pathways in the CNS. Generic: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg Pharmacology Mechanism of Actionīutalbital: Short- to intermediate-acting barbiturate. Vtol LQ: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg per 15 mL (473 mL) Įsgic: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg Generic: Butalbital 50 mg, acetaminophen 300 mg, and caffeine 40 mg, Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg Zebutal: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg Phrenilin Forte: Butalbital 50 mg, acetaminophen 300 mg, and caffeine 40 mg Margesic: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg = Discontinued productĬapacet: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mg Įsgic: Butalbital 50 mg, acetaminophen 325 mg, and caffeine 40 mgįioricet: Butalbital 50 mg, acetaminophen 300 mg, and caffeine 40 mg Excipient information presented when available (limited, particularly for generics) consult specific product labeling.
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